p53-dependent polyploidisation after DNA damage in G2 phase.
Anna Middleton, Rakesh Suman, Peter O’Toole, Karen Akopyan, Arne Lindqvist
bioRxiv 2020

Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
Anika Wiegard, Vladislav Kuzin, Donald P Cameron, Jan Grosser, Michele Ceribelli, Rashid Mehmood, Roberto Ballarino, Francesco Valant, Radosław Grochowski, Ivana Karabogdan, Nicola Crosetto, Arne Lindqvist, Anna Helene Bizard, Fedor Kouzine, Toyoaki Natsume, Laura Baranello
Mol Cell. 2021 Dec 16

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
Helena Silva Cascales, Kamila Burdova, Anna Middleton, Vladislav Kuzin, Erik Müllers, Henriette Stoy, Laura Baranello, Libor Macurek, Arne Lindqvist
Life Sci Alliance. 2021 Jan 5

FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery.
Lorenzo Lafranchi, Erik Müllers, Dorothea Rutishauser, Arne Lindqvist
Cells. 2020 Sep 19

Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers.
Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Yang Wang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira
Nucleic Acids Res. 2020 Jun 4

Neutralization of the Positive Charges on Histone Tails by RNA Promotes an Open Chromatin Structure.
Rositsa Dueva, Karen Akopyan, Chiara Pederiva, Davide Trevisan, Soniya Dhanjal, Arne Lindqvist, Marianne Farnebo
Cell Chem Biol. 2019 Oct

The Human Long Non-Coding RNA Gene RMRP Has Pleiotropic Effects and Regulates Cell-Cycle Progression at G2
Svetlana Vakkilainen, Tiina Skoog, Elisabet Einarsdottir, Anna Middleton, Minna Pekkinen, Tiina Öhman, Shintaro Katayama, Kaarel Krjutškov, Panu E Kovanen, Markku Varjosalo, Arne Lindqvist, Juha Kere, Outi Mäkitie
Sci Rep. 2019 Sep

Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG 2 M Phase.
Irena Roci, Jeramie D Watrous, Kim A Lagerborg, Lorenzo Lafranchi, Arne Lindqvist, Mohit Jain, Roland Nilsson
Cell Rep. 2019 Feb

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.
Lemmens B, Hegarat N, Akopyan K, Sala-Gaston J, Bartek J, Hochegger H, Lindqvist A
Mol Cell. 2018 Jul 5

How the cell cycle enforces senescence.
Silva Cascales H, Müllers E, Lindqvist A
Aging (Albany NY). 2017 Oct 30

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A
EMBO J. 2017 Jun 12
bioRxiv preprint

Residual Cdk1/2 activity after DNA damage promotes senescence.
Müllers E, Silva Cascales H, Burdova K, Macurek L, Lindqvist A
Aging Cell. 2017 Jun
bioRxiv preprint

Cell Cycle Dynamics of Proteins and Post-translational Modifications Using Quantitative Immunofluorescence.
Akopyan K, Lindqvist A, Müllers E.
Methods Mol Biol. 2016; 1342:173-83. doi: 10.1007/978-1-4939-2957-3_9.

Spatial Separation of Plk1 Phosphorylation and Activity.
Bruinsma W, Aprelia M, Kool J, Macurek L, Lindqvist A, Medema RH
Front Oncol. 2015 Jun 10;5:132. doi: 10.3389/fonc.2015.00132. eCollection 2015.

Bystander communication and cell cycle decisions after DNA damage.
Jaiswal H, Lindqvist A
Front Genet. 2015 Feb 27;6:63. doi: 10.3389/fgene.2015.00063. eCollection 2015.

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.
Erik Müllers, Helena Silva Cascales, Himjyot Jaiswal, Adrian T Saurin, Arne Lindqvist
Cell Cycle 2014, September 1

The chromosomal association of the smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.
Jeppsson K, Carlborg KK, Nakato R, Berta DG, Lilienthal I, Kanno T, Lindqvist A, Brink MC, Dantuma NP, Katou Y, Shirahige K, Sjögren C
PLoS Genet. 2014 Oct 16;10(10):e1004680

Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism.
Waraky A, Akopyan K, Parrow V, Strömberg T, Axelson M, Abrahmsén L, Lindqvist A, Larsson O, Aleem E
Oncotarget. 2014 Sep 30;5(18):8379-92.

Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations.
Feine O, Hukasova E, Bruinsma W, Freire R, Fainsod A, Gannon J, Mahbubani HM, Lindqvist A, Brandeis M.
Cell Cycle. 2014 Jun 1;13(11):1727-36.

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.
Peng X, Mandal PK, Kaminskyy VO, Lindqvist A, Conrad M, Arnér ES
Cell Death Dis. 2014 May 22;5:e1235.

Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on
Mäki-Jouppila JH, Laine LJ, Rehnberg J, Narvi E, Tiikkainen P, Hukasova E, Halonen P, Lindqvist A, Kallio L, Poso A, Kallio MJ.
Mol Cancer Ther. 2014 May;13(5):1054-66

Assessing Kinetics from Fixed Cells Reveals Activation of the Mitotic Entry Network at the S/G2 Transition.
Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A.
Mol Cell. 2014 Feb 25. pii: S1097-2765(14)00114-2.

Bora and Aurora-A continue to activate Plk1 in mitosis.
Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH.
J Cell Sci. 2014 Feb 15;127(Pt 4):801-11

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning.
Tame MA, Raaijmakers JA, van den Broek B, Lindqvist A, Jalink K, Medema RH.
Cell Cycle. 2014 Feb 10;13(7)

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.
Macurek L, Benada J, Müllers E, Halim VA, Krejčíková K, Burdová K, Pecháčková S, Hodný Z, Lindqvist A, Medema RH, Bartek J.
Cell Cycle. 2013 Jan 15;12(2):251-62

Monitoring kinase and phosphatase activities through the cell cycle by ratiometric FRET.
Hukasova E, Silva Cascales H, Kumar SR, Lindqvist A.
J Vis Exp. 2012 Jan 27;(59):e3410.

Functional characterization of the pleckstrin homology domain of a cellulose synthase from the oomycete Saprolegnia monoica.
Fugelstad J, Brown C, Hukasova E, Sundqvist G, Lindqvist A, Bulone V.
Biochem Biophys Res Commun. 2012 Jan 27;417(4):1248-53.

Boosting and suppressing mitotic phosphorylation.
Medema RH, Lindqvist A.
Trends Biochem Sci. 2011 Nov;36(11):578-84.

Transcriptional regulation underlying recovery from a DNA damage-induced arrest.
Alvarez-Fernández M, Medema RH, Lindqvist A.
Transcription. 2010 Jul-Aug;1(1):32-5.

Cyclin B-Cdk1 activates its own pump to get into the nucleus.
Lindqvist A.
J Cell Biol. 2010 Apr 19;189(2):197-9.

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH.
Oncogene. 2010 Apr 15;29(15):2281-91.

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.
Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A.
PLoS Biol. 2010 Apr 6;8(4):e1000350.

The decision to enter mitosis: redundancy and feedback in the mitotic entry network.
Lindqvist A, Rodriguez V and Medema RH.
Journal of Cell Biology. 2009, 185, 193-202

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
Lindqvist A, de Bruin M, Macurek L, Bras A, Mensinga A, Bruinsma W, Voets O, Kranenburg O and Medema RH.
EMBO Journal. 2009, 28, 3196-3206

Selected older publications

Polo-like kinase-1 is activated by Aurora-A to promote checkpoint recovery.
Macurek L*, Lindqvist A*, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SC, Yaffe MB and Medema RH.
Nature. 2008, 455, 119-123

Cyclin B1-Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression.
Lindqvist A, van Zon W, Karlsson Rosenthal C and Wolthuis R.
PLoS Biology. 2007, 5(5). e123.

Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating Cyclin B/Cdk1 at the centrosome.
Lindqvist A, Källström H, Lundgren A, Barsoum E and Rosenthal CK.
Journal of Cell Biology. 2005, 171, 35-45